Mixing Diazepam (Valium) and Oxycodone is a risky combination that can result in severe side effects, including respiratory depression, coma and even death. Both medications are central nervous system (CNS) depressants that work by slowing down brain function. When taken together, their sedative effects can compound, leading to dangerous consequences.
At Crossroads Treatment Centers, we are dedicated to helping those struggling with opioid addiction. Through our substance use disorder treatment, we support individuals in overcoming dependency while providing safer, healthier alternatives for pain and anxiety management.
What Are Diazepam and Oxycodone?
Diazepam, commonly known by its brand name Valium, is a benzodiazepine prescribed for conditions like anxiety, seizures, muscle spasms and insomnia. It works by increasing the activity of gamma-aminobutyric acid (GABA) in the brain, creating a calming and sedative effect. While effective in short-term use, Diazepam carries a high risk of dependence, particularly when used regularly or at higher doses.
Oxycodone is an opioid used to treat moderate to severe pain. It binds to opioid receptors in the brain, changing how the body perceives and responds to pain. Like other opioids, Oxycodone carries a high risk of addiction and potential overdose.
Both drugs are Central Nervous System (CNS) depressants. When used together, they amplify each other’s sedative properties, increasing the chances of life-threatening conditions, such as overdose and respiratory depression.

The Dangers of Mixing Diazepam and Oxycodone
Taking Diazepam and Oxycodone together greatly increases the potential for harmful effects. Each drug on its own can cause drowsiness, impaired motor function and respiratory depression. However, when combined, these effects become far more dangerous, which can lead to severe complications.
Respiratory Depression
One of the most significant risks of mixing Diazepam and Oxycodone is respiratory depression, where breathing becomes dangerously slow or shallow. It can be especially dangerous during sleep, as an individual may not notice the effects until too late. In extreme cases, respiratory depression can lead to coma or death. A healthcare provider should closely monitor anyone taking these drugs together.
Impaired Motor Skills and Cognitive Function
Mixing Diazepam and Oxycodone can severely impair cognitive abilities and motor skills. This can lead to confusion, poor judgment and difficulty with coordination, increasing the risk of accidents, especially when driving or operating machinery. It is especially concerning for those who take these medications regularly and may not be aware of how they impair mental and physical functioning.
Risk of Coma or Death
The compounded sedative effects of Diazepam and Oxycodone can lead to coma or even death. This is particularly true for individuals with underlying health conditions, such as respiratory disorders, heart disease or liver problems. The combination of these medications can overwhelm the body, leading to a complete shutdown of vital functions.
Tolerance, Dependence and Withdrawal Risks
Both Diazepam and Oxycodone carry high risks of tolerance and dependence. Tolerance occurs when a person requires higher doses of the drug to achieve the same effect, leading to increased usage. Dependence occurs when the body adapts to the drug, resulting in withdrawal symptoms when the medication is reduced or stopped.
When used together, the potential for tolerance and dependence becomes even higher. Over time, individuals may take larger doses of both medications, further increasing their risk of overdose and other serious side effects. For those struggling with the misuse of these substances, professional intervention may be necessary. The Crossroads team are experts in treating opioid use, such as Oxycodone.
Serotonin Syndrome
Although both Diazepam (Valium) and Oxycodone are CNS depressants, they can also contribute to a rare but dangerous condition called serotonin syndrome when combined with other medications. Serotonin syndrome occurs when there is too much serotonin in the brain, leading to symptoms such as confusion, rapid heart rate, high blood pressure and agitation. In severe cases, it can result in seizures or unconsciousness.
Serotonin syndrome is more likely to occur if these medications are taken alongside other drugs that also affect serotonin levels, such as certain antidepressants. Anyone using multiple medications should consult their doctor about the risks of serotonin syndrome.
Safe Alternatives to Manage Pain and Anxiety
Given the severe risks associated with combining Valium and Oxycodone, you should explore safer alternatives for pain and anxiety management. For pain, non-opioid medications, physical therapy or over-the-counter pain relievers may be recommended. For anxiety, cognitive-behavioral therapy or other non-benzodiazepine medications can bring relief without the high risks of dependence and overdose.
Seeking Help at Crossroads Treatment Centers
If you or someone you love is struggling with misuse of Diazepam and Oxycodone, getting professional help is critical. At Crossroads Treatment Centers, we offer opioid use disorder treatment designed to meet the specific needs of individuals battling opioid dependency. Our team of experienced professionals works closely with each patient to develop treatment plans that address every aspect of addiction.